Jobs

We are always interested in hearing from enthusiastic candidates that would like to join our team!

Prospective postdoctoral candidates should get in touch with Christina Ernst (christina.ernst@epfl.ch) to discuss different opportunities and funding applications, such as the SNSF Swiss Postdoctoral Fellowships.

To discuss options for internships or BSc and MSc projects, please send your CV directly to Christina Ernst (christina.ernst@epfl.ch) including the names and contact details of two references and a short description of why you are interested in joining our team.
For specific projects and opportunities please check any listings below.



R&D Internship –
NGS library preparation and sequencing

We are looking for a highly motivated intern to join our team and help us further develop and optimise a novel library preparation strategy for its application to various RNA-sequencing protocols.

The work will involve proof-of-concept and benchmarking experiments and is an ideal opportunity for current BSc/MSc students or recent graduates who wish to obtain hands-on experience in next-generation sequencing (NGS) technologies.

This is a 6-months, full-time, paid internship with affiliation to EPFL’s School of Life Sciences.


Responsibilities

You will work as part of our young and dynamic team and gain knowledge and experience in NGS technologies, design and execution of experiments, and interpretation of data. The work will have a strong R&D focus, with various optimisation and benchmarking experiments to adapt our in-house library preparation protocol to a wide range of sequencing technologies and the potential to apply the developed technology to exciting biological questions. You will be expected to keep excellent experimental records and prepare the obtained data for presentation to both internal and external audiences, with the potential to publish your work in peer-reviewed scientific journals.

Specific examples of the expected work include:

  • Optimisation of mRNA capture and fragmentation
  • Optimisation of Reverse Transcription conditions
  • Scaling of reaction conditions for low-input reaction down to single-cell applications
  • Adaptation for long-read sequencing technologies

Qualifications:

BSc or MSc in Molecular Biosciences, Biochemistry, Biotechnology, or related fields.


Required skills:

  • Familiarity with molecular biology techniques, e.g.: reverse transcription, polymerase chain reaction (PCR), agarose gel electrophoresis
  • Prior experience working with RNA, e.g.: RNA extraction, RNA quantification, RT-qPCR
  • Experience interpreting results from agarose gel electrophoresis and RT-qPCR
  • Professional working proficiency in English (ILR Level 3 or higher)

Desirable skills:

  • Experience with magnetic bead-based purification protocols
  • Experience generating next-generation sequencing (NGS) libraries
  • Experience with NGS data analysis (e.g., RNA-seq)

Start Date: 01 October 2022 or as agreed.

About Us:

We are a young research group at EPFL’s School of Life Sciences interested in all aspects of RNA biology and the development of technologies to study the expression, modifications, and interactions of RNA inside cells (ernstlab.org). This particular project is supported by the enable programme of EPFL’s Technology Transfer Office (https://www.epfl.ch/research/services/enable/), allowing us to further develop one of our technologies for wider application in the field of high-throughput sequencing.

The successful candidate will have the unique opportunity to gain hands-on experience with cutting-edge technology that drives innovation, acquiring highly relevant skills for academia and industry.

Please send applications including your CV, a cover letter stating your interest in our work and relevant research experience, as well as contact details of 2 references to christina.ernst@epfl.ch.